INHIBITION OF PEPTIDYL-ARGININE DEIMINASES REVERSES PROTEIN-HYPERCITRULLINATION AND DISEASE IN MOUSE MODELS OF MULTIPLE SCLEROSIS

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

SUMMARY Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy.We valhalla axys first discovered that abnormal myelin hypercitrullination, even in normal-appearing white matter, by peptidylarginine deiminases (PADs) correlates strongly with

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Cartography of Selce

Cartographic representations, read more both contemporary or old maps and plans, are extraordinary sources of spatial information.They contain spatial, historical, toponomastic, economical, ethnical and numerous other data important for understanding the entire development of an area.Although Selce has not been inhabited for as long as some surroun

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Dermatologic symptoms associated with gastrointestinal neoplasia

Gastrointestinal tumors are among the most common neoplastic causes of death worldwide.Presence of characteristic skin lesions can allow faster diagnosis and therapy and this way can increase the probability of a cure.In sensationnel kiyari the paper we present the most important paraneoplastic syndromes that can coexist with gastrointestinal malig

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